Harnessing Conformational Plasticity to Generate Designer Enzymes
نویسندگان
چکیده
منابع مشابه
Designer lignins: harnessing the plasticity of lignification.
Lignin is a complex polyphenolic constituent of plant secondary cell walls. Inspired largely by the recalcitrance of lignin to biomass processing, plant engineering efforts have routinely sought to alter lignin quantity, composition, and structure by exploiting the inherent plasticity of lignin biosynthesis. More recently, researchers are attempting to strategically design plants for increased ...
متن کاملHarnessing plasticity to reset dysfunctional neurons.
For a long time, it was thought that the adult mammalian brain was hard-wired and that once circuits were laid down and their functions assigned, little change was possible. This notion is no longer tenable. The brain has a lifelong inherent ability to change and adapt: individual neurons and neural circuits can change their “job descriptions” and their allegiance in response to demands. The me...
متن کاملConformational Plasticity of proNGF
Nerve Growth Factor is an essential protein that supports neuronal survival during development and influences neuronal function throughout adulthood, both in the central and peripheral nervous system. The unprocessed precursor of NGF, proNGF, seems to be endowed with biological functions distinct from those of the mature protein, such as chaperone-like activities and apoptotic and/or neurotroph...
متن کاملHarnessing plasticity to understand learning and treat disease.
A large body of evidence suggests that neural plasticity contributes to learning and disease. Recent studies suggest that cortical map plasticity is typically a transient phase that improves learning by increasing the pool of task-relevant responses. Here, I discuss a new perspective on neural plasticity and suggest how plasticity might be targeted to reset dysfunctional circuits. Specifically,...
متن کاملA skewed-momenta method to efficiently generate conformational-transition trajectories.
We present a novel computational method, the skewed-momenta method (Skew'M), which applies a bias to the Maxwell distribution of initial momenta used to generate ensembles of trajectories. As a result, conformational transitions are accentuated and kinetic properties are calculated more effectively. The connection to the related puddle jumping method is discussed. A reweighting scheme permits t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2020
ISSN: 0002-7863,1520-5126
DOI: 10.1021/jacs.0c04924